Technologies for whole-cell modeling: Genome-wide reconstruction of a cell in silico.

ABSTRACT: With advances in high-throughput, large-scale in vivo measurement and genome modification techniques at the single-nucleotide level, there is an increasing demand for the development of new technologies for the flexible design and control of cellular systems. Computer-aided design is a powerful tool to design new cells. Whole-cell modeling aims to integrate various cellular subsystems, determine their interactions and cooperative mechanisms, and predict comprehensive cellular behaviors by computational simulations on a genome-wide scale. It has been applied to prokaryotes, yeasts, and higher eukaryotic cells, and utilized in a wide range of applications, including production of valuable substances, drug discovery, and controlled differentiation. Whole-cell modeling, consisting of several t

SUBMITTER: Kaizu K 

PROVIDER: S-EPMC11520977 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature