Associations of per- and polyfluoroalkyl substances with human milk metabolomic profiles in a rural North American cohort.

ABSTRACT:

Background

Per- and polyfluoroalkyl substances (PFAS) are a class of persistent synthetic chemicals that are found in human milk and are associated with negative health effects. Research suggests that PFAS affect both lactation and the human metabolome.

Methods

We measured perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) in the milk of 425 participants from the New Hampshire Birth Cohort Study using liquid chromatography-tandem mass spectrometry (LC-MS/MS). A nontargeted metabolomics assay was performed using LC with high-resolution MS, and metabolites were identified based on in-house database matching. We observed six metabolic profiles among our milk samples using self-organizing maps, and multinomial logistic regression was used to identify sociodemographic

SUBMITTER: Criswell RL 

PROVIDER: S-EPMC11521063 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature