Serum iron status and the risk of female infertility in European populations: A two-sample Mendelian randomization study.

ABSTRACT: The relationship between iron status and female infertility has been observed in several studies, yet its causal nature remains ambiguous. We employed univariate Mendelian randomization (MR) analyses to explore the potential causal connection between these 2 factors. For our analysis, genetic instrumental variables pertaining to iron status were selected using data from the Iron Status Genetics Consortium, encompassing 48,972 individuals of European descent from 19 cohorts (11 discovery and 8 replication). For female infertility data, we referred to FinnGen Consortium Release 9, which includes 11,442 cases and 107,564 controls. Our MR approach utilized both a conservative strategy (involving single nucleotide polymorphisms pertinent to general iron status) and a liberal strategy (encompass

SUBMITTER: Liu Z 

PROVIDER: S-EPMC11521090 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature