JC Polyomavirus Nephropathy: A Rare Complication Late after Kidney Transplantation.

ABSTRACT:

Introduction

JC-polyomavirus-associated nephropathy (JC-PVAN) is a rare cause of allograft dysfunction with only a few cases described in the literature.

Case presentation

We present 2 cases of JC-PVAN, both of which occurred >5 years after kidney transplantation. In both cases, transplant biopsies were performed because of worsening of kidney function. We found tubulitis and interstitial inflammation; immunohistochemistry was positive for SV40, but BK virus was not detected. The presence of JC virus confirmed the diagnosis of JC-PVAN. Immunosuppressive therapy was adopted, but in both cases graft function progressively deteriorated.

Conclusions

Our cases show that JC-PVAN, although much rarer than BK-PVAN, should be considered a possible cause of graft dysfunction ev

SUBMITTER: Gerber JS 

PROVIDER: S-EPMC11521426 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature