Delayed Distant Recurrence of a Uveal Melanoma 4 Decades after Enucleation.

ABSTRACT:

Introduction

This report presents a case of an exceptionally delayed distant recurrence of a choroidal melanoma, occurring 4 decades after the enucleation of the affected eye.

Case presentation

In 1977, a 29-year-old man underwent enucleation for a choroidal melanoma. At the age of 68 years, he was diagnosed with advanced prostate cancer. Although the metastatic prostate cancer responded to treatment, a persistent lung lesion warranted further examination. A lung biopsy, somewhat surprisingly, confirmed the presence of melanoma metastasis, 4 decades after the enucleation. The cells were positive for Melan-A, while no BRAF mutation was identified. Two years later, new lesions appeared in the liver, and CT showed progression with multiple new sites. A liver biopsy revea

SUBMITTER: Eide NA 

PROVIDER: S-EPMC11521504 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature