JAK 2-Positive Diseases and Spontaneous Coronary Artery Dissection: Case Series.

ABSTRACT:

Introduction

Chronic myeloproliferative neoplasms (MPNs) such as polycythaemia vera (PV) and essential thrombocytosis are associated with atherosclerosis and cardiovascular events, especially if JAK2 mutation is there. In rare cases, also spontaneous coronary artery dissection (SCAD) can be seen.

Case presentation

This case series describes two case reports of MPNs in which SCAD was found in both of them in addition to standard atherosclerosis. First one was about a 42-year-old man who was admitted for acute myocardial infarction (MI) and was later found to have PV and SCAD. The second one was about a 52-year-old man who was also admitted for acute MI and was later found to have SCAD and essential thrombocythemia. JAK2V617F missense mutation was found in both cases.

Concl

SUBMITTER: Yasin AKA 

PROVIDER: S-EPMC11521505 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature