The RNA from Pseudomonas aeruginosa Reduces Neutrophil Responses Favoring Bacterial Survival.

ABSTRACT:

Introduction

Epithelial and endothelial cells modulate innate immune responses in the lung, including the arrival of neutrophils (PMN), which are crucial cells for the antibacterial host defense. Cells are exposed to prokaryotic RNA (pRNA) during bacterial infections and different pRNA may promote or attenuate the inflammatory response on different immune cells. Pseudomonas aeruginosa (PAE) can cause severe pneumonia and has several immune-evading mechanisms. The aim of this study was to determine the effects of the RNA from PAE (RNAPAE) on lung epithelial, endothelial cells, and PMN, and its impact on bacterial elimination.

Methods

Purified total RNAPAE was used as a stimulus on a human lung epithelial cell line (Calu-6), human microvascular endothelial cell line HMEC-1 and

SUBMITTER: Pittaluga JR 

PROVIDER: S-EPMC11521516 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature