Immune gene regulation is associated with age and environmental adversity in a nonhuman primate.

ABSTRACT: Phenotypic aging is ubiquitous across mammalian species, suggesting shared underlying mechanisms of aging. Aging is linked to molecular changes to DNA methylation and gene expression, and environmental factors, such as severe external challenges or adversities, can moderate these age-related changes. Yet, it remains unclear whether environmental adversities affect gene regulation via the same molecular pathways as chronological, or 'primary', aging. Investigating molecular aging in naturalistic animal populations can fill this gap by providing insight into shared molecular mechanisms of aging and the effects of a greater diversity of environmental adversities - particularly those that can be challenging to study in humans or laboratory organisms. Here, we characterised molecular aging - sp

SUBMITTER: Watowich MM 

PROVIDER: S-EPMC11521774 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature