Inhibition of angiogenesis and regenerative lung growth in <i>Lep^ob/ob</i> mice through adiponectin-VEGF/VEGFR2 signaling.

ABSTRACT:

Introduction

Obesity is associated with impairment of wound healing and tissue regeneration. Angiogenesis, the formation of new blood capillaries, plays a key role in regenerative lung growth after unilateral pneumonectomy (PNX). We have reported that obesity inhibits angiogenesis. The effects of obesity on post-PNX lung vascular and alveolar regeneration remain unclear.

Methods

Unilateral PNX is performed on Lep ^{o b / o b} obese mice to examine vascular and alveolar regeneration.

Results

Regenerative lung growth and expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR2 induced after PNX are inhibited in Lep ^{o b / o b} obese mice. The level

SUBMITTER: Hunyenyiwa T 

PROVIDER: S-EPMC11521822 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature