Myocardial infarction in rats was alleviated by MSCs derived from the maternal segment of the human umbilical cord.

ABSTRACT:

Background

Mesenchymal stem cells (MSCs) are safe and effective in treating myocardial infarction (MI) and have broad application prospects. However, the heterogeneity of MSCs may affect their therapeutic effect on the disease. We recently found that MSCs derived from different segments of the same umbilical cord (UC) showed significant difference in the expression of genes that are related to heart development and injury repair. We therefore hypothesized that those MSCs with high expression of above genes are more effective to treat MI and tested it in this study.

Methods

MSCs were isolated from 3 cm-long segments of the maternal, middle and fetal segments of the UC (maternal-MSCs, middle-MSCs and fetal-MSCs, respectively). RNA-seq was used to analyze and compare the transc

SUBMITTER: Sun S 

PROVIDER: S-EPMC11521943 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature