Epigallocatechin gallate protects mice from <i>Salmonella enterica</i> ser. Typhimurium infection by modulating bacterial virulence through quorum sensing inhibition.

ABSTRACT: Salmonella enterica ser. Typhimurium is a common pathogen that poses a considerable public health threat, contributing to severe gastrointestinal diseases and widespread foodborne illnesses. The virulence of S. Typhimurium is regulated by quorum sensing (QS) and the type III secretion system (T3SS). This study investigated the inhibitory effects and anti-QS activity of epigallocatechin gallate (EGCG), which is a bioactive ingredient found in green tea, on the virulence of S. Typhimurium. In vitro bacterial experiments demonstrated that EGCG inhibited the production of autoinducers, biofilm formation, and flagellar activity by downregulating the expression of AI-1, AI-2, Salmonella pathogenicity islands (SPI)-1, SPI-2, and genes related to flagella, fimbri

SUBMITTER: Cheng G 

PROVIDER: S-EPMC11521958 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature