Association of ACE1 I/D polymorphism and susceptibility to COVID-19 in Egyptian children and adolescents.

ABSTRACT:

Background

Given the sparse data on the renin-angiotensin system (RAS) and its biological effector molecules ACE1 and ACE2 in pediatric COVID-19 cases, we investigated whether the ACE1 insertion/deletion (I/D) polymorphism could be a genetic marker for susceptibility to COVID-19 in Egyptian children and adolescents.

Methods

This was a case-control study included four hundred sixty patients diagnosed with COVID-19, and 460 well-matched healthy control children and adolescents. The I/D polymorphism (rs1799752) in the ACE1 gene was genotyped by polymerase chain reaction (PCR), meanwhile the ACE serum concentrations were assessed by ELISA.

Results

The ACE1 D/D genotype and Deletion allele were significantly more represented in patients with COVID-19 compared to the contro

SUBMITTER: Boraey NF 

PROVIDER: S-EPMC11521986 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature