Effects of postnatal corticosteroids on lung development in newborn animals. A systematic review.

ABSTRACT:

Background

Postnatal systemic corticosteroids reduce the risk of bronchopulmonary dysplasia but the effect depends on timing, dosing, and type of corticosteroids. Animal studies may provide valuable information on these variable effects. This systematic review summarizes the effects of postnatal systemic corticosteroids on lung development in newborn animals.

Methods

A systematic search was performed in PubMed and Embase in December 2022. The protocol was published on PROSPERO (CRD42021177701).

Results

Of the 202 eligible studies, 51 were included. Only newborn rodent studies met the inclusion criteria. Most studies used dexamethasone (98%). There was huge heterogeneity in study outcome measures and corticosteroid treatment regimens. Reporting of study quality indicat

SUBMITTER: Lok IM 

PROVIDER: S-EPMC11522003 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature