Ectopic expression of the mitochondrial protein COXFA4L3 in human sperm acrosome and its potential application in the selection of male infertility treatments.

ABSTRACT:

Purpose

Spermatogenesis requires a large amount of energy, which is primarily produced by the mitochondrial electron transfer chain. Mitochondrial dysfunction affects male infertility, suggesting a relationship between the electron transfer chain and male infertility. COXFA4L3 (C15ORF48) is an emerging subunit protein of cytochrome oxidase specifically expressed in germ cells during spermatogenesis, and it may be involved in male infertility. Therefore, to investigate whether COXFA4L3 could be a marker of mitochondrial dysfunction in the sperm, this study examined the protein expression and localization profile of COXFA4L3 in the sperm of male patients with infertility.

Methods

Twenty-seven semen samples from a male infertility clinic at the Reproductive Center of Yokohama C

SUBMITTER: Fujisawa Y 

PROVIDER: S-EPMC11522028 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature