In search of epigenetic hallmarks of different tissues: an integrative omics study of horse liver, lung, and heart.

ABSTRACT: DNA methylation and microRNA (miRNA) expression are epigenetic mechanisms essential for regulating tissue-specific gene expression and metabolic processes. However, high-resolution transcriptome, methylome, or miRNAome data is only available for a few model organisms and selected tissues. Up to date, only a few studies have reported on gene expression, DNA methylation, or miRNA expression in adult equine tissues at the genome-wide level. In the present study, we used RNA-Seq, miRNA-seq, and reduced representation bisulfite sequencing (RRBS) data from the heart, lung, and liver tissues of healthy cold-blooded horses to identify differentially expressed genes (DEGs), differentially expressed miRNA (DE miRNA) and differentially methylated sites (DMSs) between three types of horse tissues. Add

SUBMITTER: Semik-Gurgul E 

PROVIDER: S-EPMC11522055 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature