Identifying the prognostic significance of mitophagy-associated genes in multiple myeloma: a novel risk model construction.

ABSTRACT: Multiple myeloma (MM) is a highly heterogeneous hematological malignancy that is currently incurable. Individualized therapeutic approaches based on accurate risk assessment are essential for improving the prognosis of MM patients. Nevertheless, current prognostic models for MM exhibit certain limitations and prognosis heterogeneity still an unresolved issue. Recent studies have highlighted the pivotal involvement of mitochondrial autophagy in the development and drug sensitivity of MM. This study seeks to conduct an integrative analysis of the prognostic significance and immune microenvironment of mitophagy-related signature in MM, with the aim of constructing a novel predictive risk model. GSE4581 and GSE47552 datasets were acquired from the Gene Expression Omnibus database. MM-different

SUBMITTER: Min R 

PROVIDER: S-EPMC11522179 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature