Anti-dengue viral activity of Glycyrrhiza glabra roots in Vero cells.

ABSTRACT: Despite being a global public health problem, there are no antiviral agents for dengue. Plants are the sources of most approved drugs and many phytochemicals have exhibited in vitro antiviral activity. We explored the antiviral potential of the aqueous extract of Glycyrrhiza glabra roots (GGaq) on dengue viruses. Plaque reduction antiviral assay for half maximal inhibitory concentrations (IC₅₀) was done in Vero cells infected with dengue serotypes 1-4 and exposed to varying concentrations of GGaq. Half-maximal cytotoxic concentration (CC₅₀) of the GGaq was 651.9 µg/mL. The IC₅₀ of the four dengue serotypes (10-50 µg/mL) indicated moderate inhibition by GGaq. 98-100% inhibition of all dengue serotypes was seen with GGaq at the maximum nontoxic dose. Preparat

SUBMITTER: Jayasekara KG 

PROVIDER: S-EPMC11522296 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature