Systems biology approaches identify metabolic signatures of dietary lifespan and healthspan across species.

ABSTRACT: Dietary restriction (DR) is a potent method to enhance lifespan and healthspan, but individual responses are influenced by genetic variations. Understanding how metabolism-related genetic differences impact longevity and healthspan are unclear. To investigate this, we used metabolites as markers to reveal how different genotypes respond to diet to influence longevity and healthspan traits. We analyzed data from Drosophila Genetic Reference Panel (DGRP) strains raised under AL and DR conditions, combining metabolomic, phenotypic, and genome-wide information. We employed two computational and complementary methods across species-random forest modeling within the DGRP as our primary analysis and Mendelian randomization in human cohorts as a secondary analysis. We pinpointed key traits with cr

SUBMITTER: Hilsabeck TAU 

PROVIDER: S-EPMC11522498 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature