Causal effect of psoriasis on aortic valve stenosis: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Epidemiological studies have suggested a potential connection between psoriasis and an increased risk of aortic valve stenosis (AS), though the impact of psoriasis on AS progression remains uncertain. The study aims to investigate the causal relationship between psoriasis and AS using Mendelian randomization (MR) analysis, as well as to uncover potential mechanisms underlying this association.

Methods

A two-sample MR analysis was conducted using publicly available summary statistics from genome-wide association studies (GWAS) of psoriasis and AS. Cis-eQTL and significant genes were identified for each causal single-nucleotide polymorphisms (SNPs), followed by pathway enrichment and protein-protein interaction (PPI) analysis for functional evaluation. Hub genes wer

SUBMITTER: Jiang KX 

PROVIDER: S-EPMC11522712 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature