The Relationship between Negative Emotions and Atrial Fibrillation: A Mendelian Randomization Study.

ABSTRACT:

Background

The relationship between negative emotions and atrial fibrillation (AF) has garnered significant attention, yet observational studies have yielded contradictory findings regarding the causal associations between the two. Our study sought to provide genetic evidence for a causal relationship between negative emotions and AF through Mendelian randomization (MR) study.

Methods

Utilizing genetic variations associated with negative emotions and AF as instrumental variables (IVs), a two-sample MR study was implemented. The potential causality between the two was initially assessed by using negative emotions as exposure and AF as outcome. Subsequently, potential reverse causality was evaluated by using AF as exposure and negative emotions as outcome. The inverse variance

SUBMITTER: Sun XT 

PROVIDER: S-EPMC11522760 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature