Efficacy and safety of natural killer cell therapy in patients with solid tumors: a systematic review and meta-analysis.

ABSTRACT:

Introduction

In 2020, global cancer statistics reported 19.3 million new cases and 10 million deaths annually, highlighting the urgent need for effective treatments. Current therapies, such as surgery, radiation, and chemotherapy, have limitations in comprehensively addressing solid tumor. Recent advances in cancer biology and immuno-oncology, including CAR-T cell therapy, show promise but face efficacy challenges against solid tumors.

Methods

This meta-analysis systematically reviewed studies from PubMed, Embase, Cochrane, and ClinicalTrials.gov databases up to May 2024 to evaluate the clinical efficacy and safety of unmodified NK cell therapies in solid tumors. The included trials focused on reporting objective response rates (ORR).

Results

Thirty-one trials involvi

SUBMITTER: Park H 

PROVIDER: S-EPMC11522797 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature