Impaired kidney function, cerebral small vessel disease and cognitive disorders: the Framingham Heart Study.

ABSTRACT:

Background and hypothesis

It remains unclear whether the relation of chronic kidney disease (CKD) with cognitive dysfunction is independent of blood pressure (BP). We evaluated kidney function in relation to premorbid BP measurements, cerebral small vessel disease (CSVD), and incident mild cognitive impairment (MCI) and dementia in Framingham Offspring Cohort participants.

Methods

We included Framingham Offspring participants free of dementia, attending an examination during midlife (exam cycle 6, baseline) for ascertainment of kidney function status, with brain magnetic resonance imaging late in life (exam cycles 7-9), cognitive outcome data, and available interim hypertension and BP assessments. We related CKD (estimated glomerular filtration rate <60 ml/min/1.73 m2) and a

SUBMITTER: Kelly DM 

PROVIDER: S-EPMC11522878 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature