Signaling Mechanism of Cuproptosis Activating cGAS-STING Immune Pathway.

ABSTRACT: Copper-mediated programmed cell death, which influences the regulation of tumor progression, is an effective approach for antitumor molecular therapy. Unlike apoptosis, copper complex-induced cuproptosis by lipid-acylated protein aggregation triggers the mitochondrial proteotoxic stress response, which could be associated with immunomodulation. However, it remains a great challenge to understand the distinctive molecular mechanisms that presumably activate immunity by cuproptosis. Here, the new nonlabeling fluorescent molecular tools of Cu-DPPZ-Py⁺ and Cu-DPPZ-Ph are synthesized and used to investigate the differential immune signaling mechanisms induced by copper-mediated cuproptosis or apoptosis. With Cu-DPPZ-Py⁺ and Cu-Elesclomol, there is strong evidence that the

SUBMITTER: Zhu C 

PROVIDER: S-EPMC11522904 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature