Developing Hyperpolarized Butane Gas for Ventilation Lung Imaging.

ABSTRACT: NMR hyperpolarization dramatically improves the detection sensitivity of magnetic resonance through the increase in nuclear spin polarization. Because of the sensitivity increase by several orders of magnitude, additional applications have been unlocked, including imaging of gases in physiologically relevant conditions. Hyperpolarized ¹²⁹Xe gas recently received FDA approval as the first inhalable gaseous MRI contrast agent for clinical functional lung imaging of a wide range of pulmonary diseases. However, production and utilization of hyperpolarized ¹²⁹Xe gas faces a number of translational challenges including the high cost and complexity of contrast agent production and imaging using proton-only (i.e., conventional) clinical MRI scanners, which are typically not s

SUBMITTER: Ariyasingha NM 

PROVIDER: S-EPMC11523004 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature