Putative retina metal/metalloid-binding proteins: molecular functions, biological processes and retina disease associations.

ABSTRACT: The mammalian retina contains high amounts of metals/metalloid-selenium. Their dyshomeostases are associated with certain retinal diseases. We carried out this bioinformatics study to identify the relationships between putative retinal metal/selenium binding proteins, their molecular functions, and biological processes. Identification of putative mouse metal/selenium binding proteins was based on known binding motifs, domains, patterns, and profiles. Annotations were obtained from Uniprot keywords 'metal binding', 'metal ion co-factors', 'selenium proteins'. Protein functions were estimated by associative frequency with key words in UniProt annotations. The raw data of five mouse proteomics PRIDE datasets (available to date) were downloaded and processed with Mascot against the mouse taxa

SUBMITTER: Ugarte M 

PROVIDER: S-EPMC11523097 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature