Sensitization of melanoma cells to standard chemotherapy: G-quadruplex binders as synergistic agents.

ABSTRACT: The use of chemotherapeutics has achieved considerable success in cancer therapy; however, their toxicity can severely impact patients' health. In this study, aiming to reduce the doses and potential side effects of traditional chemotherapeutics, we systematically treated A375MM human melanoma cells with seven clinically approved antineoplastic drugs, in combination with three well-characterized G-quadruplex (G4) ligands, using either simultaneous or sequential dosing schedules. Interestingly, the G4 binders synergized with most of the investigated anticancer drugs, with the degree of synergism being strictly dependent on both the treatment schedule and the drug sequence employed. Notably, some of the synergistic combinations showed selective toxicity toward melanoma cells over nontumorige

SUBMITTER: Persico C 

PROVIDER: S-EPMC11523109 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature