Human milk oligosaccharide profiles remain unaffected by maternal pre-pregnancy body mass index in an observational study.

ABSTRACT: Human milk oligosaccharides (HMOs) are important carbohydrates in human milk that infants cannot digest, acting as prebiotics linked to infant health. The risk of childhood obesity increases with maternal obesity, potentially mediated through the gut microbiota affected by the available HMOs. Studies on whether maternal obesity affects HMO abundance, yield conflicting results. This study aimed to investigate the HMO profile and its association with maternal obesity measured by pre-pregnancy body mass index (BMI) and infant anthropometrics. The results were discussed in the context of existing literature. 90 human milk samples were collected at 3 months postpartum from mothers in three BMI-groups: 32 normal weight (BMI: 18.5-24.99 kg/m²), 34 overweight (BMI: 25-30 kg/m²

SUBMITTER: Astono J 

PROVIDER: S-EPMC11523534 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature