Specific blockade CD73 alters the "exhausted" phenotype of T cells in head and neck squamous cell carcinoma.

ABSTRACT: The adenosine-induced immunosuppression hampers the immune response toward tumor cells and facilitates the tumor cells to evade immunosurveillance. CD73, an ecto-5-nucleotidase, is the ectoenzyme dephosphorylating extracellular AMP to adenosine. Here, using immunocompetent transgenic head and neck squamous cell carcinoma (HNSCC) mouse model, immune profiling showed high expression of CD73 on CD4⁺ and CD8⁺ T cells was associated with an "exhausted" phenotype. Further, treatment with anti-CD73 monoclonal antibody (mAb) significantly blunted the tumor growth in the mouse model, and the blockade of CD73 reversed the "exhausted" phenotype of CD4⁺ and CD8⁺ T cells through downregulation of total expression of PD-1 and CTLA-4 on T cells. Whereas the pop

SUBMITTER: Deng WW 

PROVIDER: S-EPMC11523565 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature