The prognostic role of activation of the complement pathways in the progression of advanced IgA nephropathy to end-stage renal disease.

ABSTRACT:

Introduction

The role of complement system in late stage of IgA nephropathy (IgAN) remains unknown. We therefore investigated the effects of complement system on worsening kidney function in advanced (stage 4 CKD) IgAN.

Methods

Renal specimens of 69 IgAN patients who underwent renal biopsy during stage 4 CKD between 2010 and 2021, were stained using immunofluorescence (IF) and immunohistochemistry (IHC) for glomerular complement components. The primary outcome was progression to end-stage renal disease (ESRD). Associations of complement components with baseline clinicopathological characteristics and outcomes were assessed using multivariable Cox regression and Spearman analyses.

Results

During a median follow-up of 18.0 months, 26 (37.7%) patients progressed to ESRD

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11523594 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature