Bank vole genomics links determinate and indeterminate growth of teeth.

ABSTRACT:

Background

Continuously growing teeth are an important innovation in mammalian evolution, yet genetic regulation of continuous growth by stem cells remains incompletely understood. Dental stem cells responsible for tooth crown growth are lost at the onset of tooth root formation. Genetic signaling that initiates this loss is difficult to study with the ever-growing incisor and rooted molars of mice, the most common mammalian dental model species, because signals for root formation overlap with signals that pattern tooth size and shape (i.e., cusp patterns). Bank and prairie voles (Cricetidae, Rodentia, Glires) have evolved rooted and unrooted molars while retaining similar size and shape, providing alternative models for studying roots.

Results

We assembled a de novo genome

SUBMITTER: Calamari ZT 

PROVIDER: S-EPMC11523675 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature