Association between the soluble receptor for advanced glycation end products and diabetes mellitus: systematic review and meta-analysis.

ABSTRACT:

Background and aims

In both type 1 diabetes (T1DM) and type 2 diabetes (T2DM), previous studies have yielded inconsistent findings regarding whether the levels of the soluble receptor for advanced glycation end products (sRAGE) are significantly altered. This meta-analysis aims to systematically evaluate the changes of sRAGE levels in patients with T1DM and T2DM.

Methods

PubMed, Embase, and Web of Science were systematically searched from inception until April 2024. We included studies reporting sRAGE levels in individuals with T1DM or T2DM, using non-diabetic healthy individuals as the control group. A random-effects model was applied to conduct a meta-analysis of effect measures (means and SDs).

Results

49 datasets from 32 studies, involving 4948 subjects, met the i

SUBMITTER: Chen Q 

PROVIDER: S-EPMC11523792 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature