B7-H3 is widely expressed in soft tissue sarcomas.

ABSTRACT:

Purpose

Targeted therapy development in soft tissue sarcoma (STS) has been burdened by the heterogeneity of this group of rare tumors. B7 homolog 3 protein (B7-H3) is a molecule in the same family as programmed death-ligand 1 (PD-L1). It has limited expression in noncancerous tissues and is overexpressed in many cancers, making it an attractive target for cancer therapy, and clinical trials targeting B7-H3 are actively underway. While available data demonstrate high expression levels of B7-H3 in individual sarcoma subtypes, its expression patterns across STS subtypes are not well described. The purpose of this study was to characterize the expression patterns of B7-H3 in STS.

Patients and methods

This retrospective analysis evaluated STS tumor specimens from patients with a

SUBMITTER: Lynch MM 

PROVIDER: S-EPMC11523878 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature