Genetical effects of sleep traits on postpartum depression: a bidirectional two-sample Mendelian randomization study.

ABSTRACT:

Background

Postpartum depression (PPD) is widely recognized as the most prevalent mental health crisis following childbirth and has been linked to sleep disturbances. However, the potential causal relationships between various sleep traits and PPD remain unclear. This study employs a bidirectional two-sample Mendelian randomization (MR) approach to investigate these associations.

Methods

The inverse-variance-weighted method was used to evaluate the causally linked sleep traits on postpartum depression. The weighted median, weighted mode, and MR-Egger were used to estimate the robustness of the inverse-variance-weighted method. The leave-one-out method estimated the sensitivity of the result. Cochran's Q method was used for the heterogeneous test. The MR-Egger intercept and M

SUBMITTER: Hu Q 

PROVIDER: S-EPMC11523897 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature