New insights into macrophage polarization and its prognostic role in patients with colorectal cancer liver metastasis.

ABSTRACT:

Background

As liver metastasis is the most common cause of mortality in patients with colorectal cancer, studying colorectal cancer liver metastasis (CLM) microenvironment is essential for improved understanding of tumor biology and to identify novel therapeutic targets.

Methods

We used a multiplex immunofluorescence platform to study tumor associated macrophage (TAM) polarization and adaptive T cell subtypes in tumor samples from 105 CLM patients (49 without and 56 with preoperative chemotherapy).

Results

CLM exhibited M2 macrophage polarization, and helper T cells were the prevalent adaptive T cell subtype. The density of total, M2 and TGFβ-expressing macrophages, and regulatory T cells was lower in CLM treated with preoperative chemotherapy. CLM with right-sided pr

SUBMITTER: Khanduri I 

PROVIDER: S-EPMC11523988 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature