Malignant peritoneal mesothelioma interactome with 417 novel protein-protein interactions.

ABSTRACT:

Background

Malignant peritoneal mesothelioma (MPeM) is an aggressive cancer affecting the abdominal peritoneal lining and intra-abdominal organs, with a median survival of ~2.5 years.

Methods

We constructed the protein interactome of 59 MPeM-associated genes with previously known protein-protein interactions (PPIs) as well as novel PPIs predicted using our previously developed HiPPIP computational model and analysed it for transcriptomic and functional associations and for repurposable drugs.

Results

The MPeM interactome had over 400 computationally predicted PPIs and 4700 known PPIs. Transcriptomic evidence validated 75.6% of the genes in the interactome and 65% of the novel interactors. Some genes had tissue-specific expression in extramedullary hematopoietic sites

SUBMITTER: Karunakaran KB 

PROVIDER: S-EPMC11524009 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature