Machine learning-optimized non-invasive brain stimulation and treatment response classification for major depression.

ABSTRACT:

Background/objectives

Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation intervention that shows promise as a potential treatment for depression. However, the clinical efficacy of tDCS varies, possibly due to individual differences in head anatomy affecting tDCS dosage. While functional changes in brain activity are more commonly reported in major depressive disorder (MDD), some studies suggest that subtle macroscopic structural differences, such as cortical thickness or brain volume reductions, may occur in MDD and could influence tDCS electric field (E-field) distributions. Therefore, accounting for individual anatomical differences may provide a pathway to optimize functional gains in MDD by formulating personalized tDCS dosage.

Methods

To

SUBMITTER: Albizu A 

PROVIDER: S-EPMC11524011 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature