Retrospective evaluation of plasma protein tumour markers for early lung cancer detection.

ABSTRACT:

Background

Blood-based biomarkers might help lung cancer diagnosis. A panel of serum tumour markers (TM) has been validated for hospital referrals due to clinical suspicion of lung cancer. We have compared plasma from a cohort enriched for early-stage lung cancer, including controls from a healthy population cohort.

Methods

TM assays for CEA, CYFRA 21-1, CA15.3, ProGRP and SCC were run on a Roche Elecsys 2010 Immunoassay Analyser for a retrospective, nested case-control cohort from the Liverpool Lung Project. The primary endpoints were the sensitivity and specificity of a pre-defined TM panel using published thresholds.

Results

Except for ProGRP, TM levels were significantly higher in cases and ROC AUC values demonstrated significant discriminant power. Accuracy and l

SUBMITTER: Davies MPA 

PROVIDER: S-EPMC11524055 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature