Comparative effectiveness of sodium-glucose cotransporter-2 inhibitors for recurrent nephrolithiasis among patients with pre-existing nephrolithiasis or gout: target trial emulation studies.

ABSTRACT:

Objective

To emulate target trials comparing recurrence of nephrolithiasis among patients with pre-existing nephrolithiasis (overall and stratified by concomitant gout) initiating sodium-glucose cotransporter-2 (SGLT-2) inhibitors versus an active comparator.

Design

Target trial emulation studies.

Setting

Canadian population database, January 2014 to June 2022.

Participants

20 146 patients with nephrolithiasis and type 2 diabetes, including those with concomitant gout at baseline, a high risk group.

Interventions

Initiation of an SGLT-2 inhibitor or glucagon-like peptide-1 (GLP-1) receptor agonist, with a dipeptidyl peptidase-4 (DPP-4) inhibitor as alternative comparator.

Main outcome measures

The primary outcome was recurrent nephrolithiasis even

SUBMITTER: McCormick N 

PROVIDER: S-EPMC11524131 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature