Temporal evolution and inter-patient heterogeneity in primary and recurrent head and neck squamous cell carcinoma.

ABSTRACT:

Background

Head and neck squamous cell carcinomas (HNSCCs) are heterogeneous in terms of origin and aetiology. In addition, there is uncertainty about the genetic evolution from initial diagnosis to recurrence after primary treatments and further disease progression following systemic treatment. Changes in the genetic profile have implications on the selection of appropriate treatments for patients, especially in the era of targeted therapies and immunotherapies.

Methods

We analysed a cohort of nine HNSCC patients with metachronous recurrence. All patients had paired primary and recurrent samples suitable for whole-exome sequencing, while transcriptomic data from seven patients could be analysed (multiple recurrent samples collected at different time points were available fo

SUBMITTER: Bresadola L 

PROVIDER: S-EPMC11524138 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature