Microglia cannibalism and efferocytosis leads to shorter lifespans of developmental microglia.

ABSTRACT: The overproduction of cells and subsequent production of debris is a universal principle of neurodevelopment. Here, we show an additional feature of the developing nervous system that causes neural debris-promoted by the sacrificial nature of embryonic microglia that irreversibly become phagocytic after clearing other neural debris. Described as long-lived, microglia colonize the embryonic brain and persist into adulthood. Using transgenic zebrafish to investigate the microglia debris during brain construction, we identified that unlike other neural cell types that die in developmental stages after they have expanded, necroptosis-dependent microglial debris is prevalent when microglia are expanding in the zebrafish brain. Time-lapse imaging of microglia demonstrates that this debris is can

SUBMITTER: Gordon H 

PROVIDER: S-EPMC11524473 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature