Human monocyte subtype expression of neuroinflammation- and regeneration-related genes is linked to age and sex.

ABSTRACT: Aging profoundly affects the immune system leading to an increased propensity for inflammation. Age-related dysregulation of immune cells is implicated in the development and progression of numerous age-related diseases such as: cardiovascular diseases, neurodegenerative disorders, and metabolic syndromes. Monocytes and monocyte-derived macrophages, being important players in the inflammatory response, significantly influence the aging process and the associated increase in inflammatory disease risk. Ischemic stroke is among age-related diseases where inflammation, particularly monocyte-derived macrophages, plays an important deteriorating role but could also strongly promote post-stroke recovery. Also, biological sex influences the incidence, presentation, and outcomes of ischemic stroke,

SUBMITTER: Tampe JF 

PROVIDER: S-EPMC11524521 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature