Inhibition of Sirtuin Deacylase Activity by Peroxynitrite.

ABSTRACT: Sirtuins are a class of enzymes that deacylate protein lysine residues using NAD⁺ as a cosubstrate. Sirtuin deacylase activity has been historically regarded as protective; loss of sirtuin deacylase activity potentially increases susceptibility to aging-related disease development. However, which factors may inhibit sirtuins during aging or disease is largely unknown. Increased oxidant and inflammatory byproduct production damages cellular proteins. Previously, we and others found that sirtuin deacylase activity is inhibited by the nitric oxide (NO)-derived cysteine post-translational modification S-nitrosation. However, the comparative ability of the NO-derived oxidant peroxynitrite (ONOO^-) to affect human sirtuin activity had not yet been assessed under unifo

SUBMITTER: Bohl K 

PROVIDER: S-EPMC11524680 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature