Extracellular matrix protein 1 binds to connective tissue growth factor against liver fibrosis and ductular reaction.

ABSTRACT:

Background

Extracellular matrix protein 1 (ECM1) can inhibit TGFβ activation, but its antifibrotic action remains largely unknown. This study aims to investigate ECM1 function and its physical interaction with the profibrotic connective tissue growth factor (CTGF) in fibrosis and ductular reaction (DR).

Methods

Ecm1 knockouts or animals that ectopically expressed this gene were subjected to induction of liver fibrosis and DR by feeding 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) or α-naphthyl-isothiocyanate (ANIT). ECM1 and CTGF were also examined in the livers of patients with alcohol-associated liver disease (ALD) or ethanol-exposed animals that were fed the western diet for 4 months in the WDA model with liver pathology resembing ALD in patients.

Results

ECM1 b

SUBMITTER: Sun C 

PROVIDER: S-EPMC11524739 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature