Association between HIV and cytomegalovirus and neurocognitive outcomes among children with HIV.

ABSTRACT:

Objectives

Children with HIV may experience adverse neurocognitive outcomes despite antiretroviral therapy (ART). Cytomegalovirus (CMV) is common in children with HIV. Among children on ART, we examined the influences of early HIV viral load and CMV DNA on neurocognition.

Design

We determined the association between pre-ART viral load, cumulative viral load, and CMV viremia and neurocognition using data from a cohort study.

Methods

Children who initiated ART before 12 months of age were enrolled from 2007 to 2010 in Nairobi, Kenya. Blood was collected at enrollment and every 6 months thereafter. Four neurocognitive assessments with 12 domains were conducted when children were a median age of 7 years. Primary outcomes included cognitive ability, executive function, att

SUBMITTER: Neary J 

PROVIDER: S-EPMC11524778 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature