Evaluation of a three-gene methylation model for correlating lymph node metastasis in postoperative early gastric cancer adjacent samples.

ABSTRACT:

Background

Lymph node metastasis (LNM) has a profound impact on the treatment and prognosis of early gastric cancer (EGC), yet the existing evaluation methods lack accuracy. Recent research has underscored the role of precancerous lesions in tumor progression and metastasis. The objective of this study was to utilize the previously developed EGC LNM prediction model to further validate and extend the analysis in paired adjacent tissue samples.

Methods

We evaluated the model in a monocentric study using Methylight, a methylation-specific PCR technique, on postoperative fresh-frozen EGC samples (n = 129) and paired adjacent tissue samples (n = 129).

Results

The three-gene methylation model demonstrated remarkable efficacy in both EGC and adjacent tissues. The model demo

SUBMITTER: Chen S 

PROVIDER: S-EPMC11524798 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature