Distinct lower respiratory tract microbiota profiles linked to airway mucus hypersecretion in children with <i>Mycoplasma pneumoniae</i> pneumonia.

ABSTRACT:

Background

Airway mucus hypersecretion (AMH) can occur in children with acute respiratory diseases, but its underlying mechanisms and relationship with the lower respiratory tract microbiota (LRTM) are not yet fully understood. This study investigates the characteristics of LRTM in children with Mycoplasma pneumoniae pneumonia (MPP) and its impact on AMH.

Methods

We collected bronchoalveolar lavage fluid and related clinical indicators from 202 children with MPP. 16S rRNA gene amplicon sequencing was used for detection and identification. Microbial diversity and characteristic genera were compared, and their abundance was analyzed for correlations with clinical factors.

Results

As the disease course (days from onset to bronchoscopy, grouped into T1, T2, T3) ext

SUBMITTER: Wei X 

PROVIDER: S-EPMC11524823 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature