MOIRE: a software package for the estimation of allele frequencies and effective multiplicity of infection from polyallelic data.

ABSTRACT:

Motivation

Malaria parasite genetic data can provide insight into parasite phenotypes, evolution, and transmission. However, estimating key parameters such as allele frequencies, multiplicity of infection (MOI), and within-host relatedness from genetic data is challenging, particularly in the presence of multiple related coinfecting strains. Existing methods often rely on single nucleotide polymorphism (SNP) data and do not account for within-host relatedness.

Results

We present Multiplicity Of Infection and allele frequency REcovery (MOIRE), a Bayesian approach to estimate allele frequencies, MOI, and within-host relatedness from genetic data subject to experimental error. MOIRE accommodates both polyallelic and SNP data, making it applicable to diverse genotyping panels. W

SUBMITTER: Murphy M 

PROVIDER: S-EPMC11524891 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature