Causal relationship between ankylosing spondylitis and ocular inflammatory diseases: a Mendelian randomization study.

ABSTRACT:

Background

Observational studies have shown an increased risk of ocular inflammatory diseases in patients with ankylosing spondylitis (AS), but the genetically predicted association remains unclear. The aim of this study was to systematically assess the causal relationship between AS and ocular inflammatory diseases.

Methods

We conducted a two-sample Mendelian randomization (MR) analysis to investigate the causal relationship between AS and several common ocular inflammatory diseases based on genome-wide association study (GWAS) data and public health data. Five methods, namely, inverse-variance weighted (IVW), MR-Egger, weighted median, weighted mode, and simple mode, were used. Sensitivity analysis was performed using MR-Egger intercept, Mendelian Randomization Pleiotropy

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11524906 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature