Immunomodulatory effect of bovine lactoferrin during SARS-CoV-2 infection.

ABSTRACT:

Introduction

Lactoferrin (Lf) is an important immunomodulator in infections caused by different agents. During SARS-CoV-2 infection, Lf can hinder or prevent virus access to the intracellular environment. Severe cases of COVID-19 are related to increased production of cytokines, accompanied by a weak type 1 interferon response.

Methods

We investigated the influence of bovine Lf (bLf) in the immune response during SARS-CoV-2 infection in vitro and in vivo assays.

Results

Our results show a strong binding between bLf and TLR4/NF-κB in silico, as well as an increase in mRNA expression of these genes in peripheral blood mononuclear cells (PBMCs) treated with bLf. Furthermore, the treatment increased TLR4/TLR9 mRNA expression in infected K18-hAC

SUBMITTER: da Silva AMV 

PROVIDER: S-EPMC11524939 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature