Systematic literature review on early clinical evidence for immune-resolution therapies and potential benefits to patients and healthcare providers.

ABSTRACT:

Introduction

Several current therapies for autoimmune diseases do not provide sustained remission. Therapies that focus on the restoration of homeostasis within the immune system (i.e., immune resolution) could overcome the limitations of current therapies and provide more durable remission. However, there is no established consensus on appropriate clinical trial designs and endpoints to evaluate such therapies. Therefore, we conducted a systematic literature review (SLR) focusing on five index diseases (asthma, atopic dermatitis, rheumatoid arthritis, systemic lupus erythematosus [SLE], and ulcerative colitis) to explore published literature on 1) expert opinion on immune-resolution outcomes that should be measured in clinical trials; and 2) quantification of immune resolution in

SUBMITTER: Klekotka P 

PROVIDER: S-EPMC11524942 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature